Obstetrics/Gynecology

FcRn protects IgG and albumin from catabolism, transports IgG across the placenta, and regulates IgG function. Blocking or augmenting FcRn can decrease autoimmune antibodies and enhance drug delivery.

As the fossil-fuel industry continues to obstruct efforts to curtail pollution from its products, the health community should use strategies that have been effective in fighting other health-harming industries.

A 2-month-old boy was brought to the clinic with a 2-week history of red spots on his face. On examination, annular plaques with edematous borders and central crusting were observed on his face, scalp, and trunk.

The alternate splicing small molecule risdiplam, administered to a fetus with spinal muscular atrophy, had an apparent ameliorating effect on the disorder through 30 months.

In this study, implementation of the Safer Births program, a bundle of interventions to improve the quality of care around the time of birth, was associated with a significant reduction in perinatal mortality.

Infertility is common, and the age of the female partner is the main predictor of live birth. Reproductive issues in men are common and can be effectively managed. In vitro fertilization is highly effective.

The current U.S. political landscape poses escalating challenges for transgender health. Clinicians, researchers, policymakers, and advocates can act to counteract regressive policies.

The addition of combined oral and topical antimicrobial therapy for male partners to treatment of women for bacterial vaginosis resulted in a lower rate of recurrence within 12 weeks than treatment of the woman alone.

Bacterial vaginosis, the most common cause of vaginal discharge in reproductive-age women,¹ is associated with multiple consequential adverse outcomes, including an increased risk of adverse birth outcomes, acquisition of human immunodeficiency virus and other sexually transmitted infections (STIs), pelvic inflammatory disease, and a high incidence of symptomatic recurrence.

Tubal ectopic pregnancy can be life-threatening. Management strategies include surgical treatment (salpingectomy or salpingostomy), medical treatment (methotrexate), or, in selected cases, expectant management.

Maternal platelet-activating anti–platelet factor 4 antibodies led to cerebral venous sinus thrombosis, thrombocytopenia, hyperfibrinolysis, and cerebral bleeding in a neonate.

A legal technique deployed by Utah to restrict gender-affirming care for minors aims at a core component of the clinician–patient relationship: clinicians’ ability to rely on patients’ informed consent.

The Cass Review on gender-affirming care, which has been used to justify bans in U.S. states, transgresses medical law, policy, and practice, which puts it at odds with mainstream U.S. expert guidelines.

Clinicians relying on shield laws to provide telehealth abortion services to patients in abortion-restrictive states face uncertain legal protections.

As she cares for a newborn who’s struggling to breathe, a neonatologist contemplates how politics and power structures affect the availability of critical perinatal services in the United States.

This interactive feature describes a woman who received a diagnosis of hypertension and preeclampsia at 27 years of age. After giving birth, her blood pressure remained elevated. Test your diagnostic and therapeutic skills at NEJM.org.

A 31-year-old woman was evaluated at 35 weeks 2 days’ gestation for a vaginal lesion. On examination, a nontender purple mass originating from the vaginal wall on the left side protruded into the introitus.

Beyond ensuring access to gender-affirming surgical care, U.S. carceral facilities can develop health care, housing, and security policies that recognize gender-affirming care as standard practice.

A 35-year-old woman was admitted at 8 weeks postpartum because of shortness of breath and edema in the legs. Proteinuria had developed at the end of the pregnancy. A diagnosis was made.

Accounting for approximately 350,000 deaths annually worldwide, cervical cancer is preventable with HPV vaccination and screening. Newer chemotherapy, radiotherapy, and immunotherapy techniques have improved survival.