Continuing Medical Education
The NEJM Weekly CME Program offers one AMA PRA Category 1 Credit™ for each successfully completed Weekly CME or Interactive Medical Case activity. A personal subscription to NEJM provides free access to the entire collection of more than 300 NEJM Weekly CME activities and Interactive Medical Cases. Track completions and download certificates through My Activities.
For help in meeting specially designated pain management and end-of-life care requirements, free CME courses on these topics are available from NEJM Group and from the Massachusetts Medical Society.
1-20 of 327 results
- In this randomized trial involving patients with noncystic fibrosis bronchiectasis, the rate of pulmonary exacerbations over a 52-week period was lower with brensocatib (10 mg or 25 mg per day) than with placebo.
- A 56-year-old woman experiencing homelessness was evaluated at this hospital because of sore throat and a pruritic rash on her face, chest, abdomen, and legs. A diagnosis was made.
- In this randomized trial conducted over the 2019–2024 influenza seasons, baloxavir resulted in a significantly lower incidence of transmission of influenza virus from patients to household contacts than placebo.
- This review considers enteral nutrition in the context of disease-related malnutrition, provides evidence for the use of enteral nutrition in hospitalized patients, and discusses practice considerations.
- A 79-year-old woman was evaluated for cough and weight loss. Chest imaging and thoracentesis findings confirmed the presence of an exudative right pleural effusion. A diagnosis was made.
- In this trial, obinutuzumab, a humanized type II anti-CD20 monoclonal antibody, plus standard therapy provided significantly better renal responses than standard therapy alone in patients with lupus nephritis.
- A 32-year-old woman was admitted with flank pain, fever, and hypoxemia. Imaging showed multifocal pulmonary opacities, pulmonary embolism, and renal vein thromboses. A diagnosis was made.
- In this trial involving 543 patients with stroke due to occlusion of medium or distal vessels, endovascular treatment within 24 hours after the onset of symptoms was not effective in improving functional outcome at 90 days.
- Acute otitis media occurs almost exclusively after a viral upper respiratory tract infection. Children with mild or moderate symptoms can be treated with antibiotics or closely observed.
- In a trial involving patients with active cancer and venous thromboembolism, extended anticoagulation with reduced-dose apixaban was noninferior to full-dose apixaban for preventing recurrent thromboembolic events.
- In patients with posterior circulation stroke for whom thrombectomy was not planned, alteplase administered 4.5 to 24 hours after stroke onset resulted in less disability at 90 days than standard treatment.
- In this phase 3 trial, the incidence of HIV infection with twice-yearly lenacapavir was lower than both the background incidence and the incidence with emtricitabine–tenofovir disoproxil fumarate.
- After atrial fibrillation ablation, left atrial appendage closure was associated with a lower risk of bleeding than oral anticoagulation and was noninferior to oral anticoagulation with respect to clinical outcomes at 36 months.
- An estimated 263 million cases of malaria and 597,000 deaths from malaria occurred worldwide in 2023. Despite progress with vaccines and an increased number of malaria-free countries, malaria remains a formidable challenge.
- In this trial, patients with type 2 diabetes had a lower incidence of major cardiovascular outcomes with a systolic blood-pressure target of less than 120 mm Hg than with a target of less than 140 mm Hg.
- The selective estrogen-receptor degrader imlunestrant plus abemaciclib led to a median progression-free survival of 9.4 months among patients with ER-positive, HER2-negative breast cancer (vs. 5.5 months with imlunestrant alone).
- In a trial involving 135 participants with IgG4-related disease, inebilizumab was associated with significantly lower flare risk and greater likelihood of complete remission than placebo at 1 year.
- A 59-year-old man with a history of metabolic dysfunction–associated steatotic liver disease had an enlarging liver mass. Biopsy showed hepatocellular carcinoma. Management decisions were made.
- In a trial involving patients with subarachnoid hemorrhage and anemia, liberal transfusion of red cells did not result in a lower risk of an unfavorable neurologic outcome than a more restrictive strategy.
- Infertility is common, and the age of the female partner is the main predictor of live birth. Reproductive issues in men are common and can be effectively managed. In vitro fertilization is highly effective.
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