Endocrinology
This review considers enteral nutrition in the context of disease-related malnutrition, provides evidence for the use of enteral nutrition in hospitalized patients, and discusses practice considerations.
In this trial, patients with type 2 diabetes had a lower incidence of major cardiovascular outcomes with a systolic blood-pressure target of less than 120 mm Hg than with a target of less than 140 mm Hg.
Among participants with type 2 diabetes and cardiovascular disease, chronic kidney disease, or both, oral semaglutide (14 mg) was associated with a lower risk of cardiovascular events than placebo after 4 years of follow-up.
Some pharmaceutical companies have launched platforms that direct users to websites run by telehealth companies, where clinicians are available to prescribe drugs. Such arrangements have prompted concerns.
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- In this trial of the aldosterone synthase inhibitor lorundrostat in participants with uncontrolled hypertension, lorundrostat was associated with greater reductions in blood pressure than placebo.
- This review considers enteral nutrition in the context of disease-related malnutrition, provides evidence for the use of enteral nutrition in hospitalized patients, and discusses practice considerations.
- Among participants with type 2 diabetes and cardiovascular disease, chronic kidney disease, or both, oral semaglutide (14 mg) was associated with a lower risk of cardiovascular events than placebo after 4 years of follow-up.
- Some pharmaceutical companies have launched platforms that direct users to websites run by telehealth companies, where clinicians are available to prescribe drugs. Such arrangements have prompted concerns.
- In this trial, patients with type 2 diabetes had a lower incidence of major cardiovascular outcomes with a systolic blood-pressure target of less than 120 mm Hg than with a target of less than 140 mm Hg.
- In a trial involving 135 participants with IgG4-related disease, inebilizumab was associated with significantly lower flare risk and greater likelihood of complete remission than placebo at 1 year.
- In this audio interview, Editor-in-Chief Eric Rubin and Deputy Editor Jane Leopold discuss research being presented at the 2024 American Heart Association Scientific Sessions. . . .
- Elevated blood pressure mediates much of the organ toxicity affecting persons with type 2 diabetes. The management of hypertension occupies as much clinical attention as that of dysglycemia, yet the recommended blood-pressure target in type 2 diabetes remains controversial. The Systolic Blood Pressure Intervention Trial (SPRINT; 9361 participants), which excluded...
- IgG4-related disease is an increasingly recognized fibroinflammatory condition with protean manifestations. The disorder is characterized by inflammatory mass lesions that can involve many different organs and organ systems — including the pancreas and biliary tract, orbital structures, salivary and lacrimal glands, lungs, retroperitoneum, and kidneys — and can also cause...
- In this randomized, controlled trial involving adults with insulin-treated type 2 diabetes, automated insulin delivery resulted in lower glycated hemoglobin levels than continuous glucose monitoring alone.
- A 72-year-old woman with type 2 diabetes had somnolence after a urologic procedure for bladder cancer. She had respiratory acidosis and anion-gap metabolic acidosis. A diagnosis was made.
- This interactive feature describes a 46-year-old patient requesting initiation of estrogen therapy. Test your diagnostic and therapeutic skills at NEJM.org.
- A woman with a history of metastatic small-cell lung cancer and Cushing’s syndrome was found to have reduced skin thickness, a possible result of antianabolic effects of excess cortisol. Methods of measuring skin thickness are shown in videos.
- Infertility is common, and the age of the female partner is the main predictor of live birth. Reproductive issues in men are common and can be effectively managed. In vitro fertilization is highly effective.
- The current U.S. political landscape poses escalating challenges for transgender health. Clinicians, researchers, policymakers, and advocates can act to counteract regressive policies.
- One third of people worldwide have at least one micronutrient deficiency. National surveys provide cross-sectional data, but inferring causality between deficiency and disease is difficult.
- A 3-year study of tirzepatide in participants with obesity and prediabetes showed substantial and sustained weight reduction and decreased risk of progression to diabetes with tirzepatide, as compared with placebo.
- Thanks to advances in both basic and clinical research, the past 20 years have seen new awareness regarding the diagnosis, treatment, and unmet needs of persons with rare genetic disorders. Most inherited bone disorders are among such rare conditions. Achondroplasia, the most common skeletal dysplasia, is characterized by disproportionate short...
- This feature about a woman with diabetic ketoacidosis offers a case vignette accompanied by two essays, one supporting the use of balanced crystalloid fluids for fluid resuscitation and the other recommending the use of isotonic saline.
- A phase 2 dose-finding study evaluated the safety and efficacy of infigratinib, an orally bioavailable FGFR1–3 selective tyrosine kinase inhibitor, in children with achondroplasia.