Cardiology
Lepodisiran, an extended-duration, small interfering RNA, reduced lipoprotein(a) concentrations in participants with elevated levels.
A 26-year-old man presented with acute leg pain and loss of function in the left leg. CTA of the abdomen showed a saddle embolus at the aortoiliac junction. A heterogeneous mass was seen in the left atrium.
This feature about a woman with device-detected atrial fibrillation offers a case vignette accompanied by two essays, one supporting the initiation of anticoagulant therapy and the other recommending continuation of antiplatelet therapy.
Among adults with pulmonary arterial hypertension at high risk for death, sotatercept reduced the risk of a composite of death from any cause, lung transplantation, or hospitalization for worsening pulmonary arterial hypertension.
In a randomized trial, pulsed field ablation was noninferior to cryoballoon ablation with respect to the incidence of a first recurrence of atrial tachyarrhythmia, as assessed by continuous rhythm monitoring.
Using data from 2,078,948 participants from 39 countries, researchers calculated lifetime estimates of cardiovascular disease and death from any cause according to the presence or absence of cardiovascular risk factors.
In a randomized trial, the routine use of cerebral embolic protection during TAVI did not reduce the incidence of stroke within 72 hours or before discharge from the hospital (if discharge occurred sooner).
Among participants with type 2 diabetes and cardiovascular disease, chronic kidney disease, or both, oral semaglutide (14 mg) was associated with a lower risk of cardiovascular events than placebo after 4 years of follow-up.
Among older patients undergoing TAVI, dapagliflozin led to a lower incidence of a composite of death from any cause or worsening of heart failure than standard care at 1 year.
In a trial involving patients with active cancer and venous thromboembolism, extended anticoagulation with reduced-dose apixaban was noninferior to full-dose apixaban for preventing recurrent thromboembolic events.
- This feature about a woman with device-detected atrial fibrillation offers a case vignette accompanied by two essays, one supporting the initiation of anticoagulant therapy and the other recommending continuation of antiplatelet therapy.
- Lepodisiran, an extended-duration, small interfering RNA, reduced lipoprotein(a) concentrations in participants with elevated levels.
- A 26-year-old man presented with acute leg pain and loss of function in the left leg. CTA of the abdomen showed a saddle embolus at the aortoiliac junction. A heterogeneous mass was seen in the left atrium.
- Intervention to reduce the levels of circulating low-density lipoprotein (LDL) cholesterol and its major protein, apolipoprotein B, is one of the most effective ways to reduce the risk of cardiovascular events. However, even with aggressive lowering of the LDL cholesterol level, the risk of cardiovascular disease is not eliminated. One...
- As the fossil-fuel industry continues to obstruct efforts to curtail pollution from its products, the health community should use strategies that have been effective in fighting other health-harming industries.
- In this trial of the aldosterone synthase inhibitor lorundrostat in participants with uncontrolled hypertension, lorundrostat was associated with greater reductions in blood pressure than placebo.
- Atrial fibrillation is the most common cardiac arrhythmia that is encountered in clinical practice, with some 4.5% of the general population affected in the United States. It has been nearly 30 years since Haïssaguerre and colleagues discovered that atrial fibrillation was a triggered arrhythmia initiated by repetitive discharges originating from...
- In a randomized trial, pulsed field ablation was noninferior to cryoballoon ablation with respect to the incidence of a first recurrence of atrial tachyarrhythmia, as assessed by continuous rhythm monitoring.
- In January, the FDA proposed substantially limiting the level of nicotine permitted in cigarettes. The proposal is expected to face strong industry opposition during a time of political uncertainty.
- With the aging of the population, aortic stenosis affects a growing number of patients, with a prevalence of 12.4% among persons who are at least 75 years of age, among whom 3.4% have severe aortic stenosis.1 Aortic stenosis is generally well tolerated for a prolonged period of time,...
- In a trial involving patients with active cancer and venous thromboembolism, extended anticoagulation with reduced-dose apixaban was noninferior to full-dose apixaban for preventing recurrent thromboembolic events.
- In a trial involving patients with ischemic stroke due to medium-vessel occlusion, thrombectomy within 12 hours did not lead to a better functional outcome and lower mortality at 90 days than usual care.
- Few procedures have gone through a decade of practice-changing clinical trials as impressive as thrombectomy for stroke. Beginning in 2015 with multiple trials showing a benefit with thrombectomy in early large-vessel occlusion, followed by the extended-window trials in 2018 and then the large core trials in 2023, it seemed that...
- In this trial involving 543 patients with stroke due to occlusion of medium or distal vessels, endovascular treatment within 24 hours after the onset of symptoms was not effective in improving functional outcome at 90 days.
- Among older patients undergoing TAVI, dapagliflozin led to a lower incidence of a composite of death from any cause or worsening of heart failure than standard care at 1 year.
- Venous thromboembolism is a common complication of cancer and its treatments, and the incidence of recurrent thrombosis, serious bleeding, and death is higher among patients with this condition than in the general population. More than 20 years have passed since Lee et al.1 reported the results of the...
- In this U.S. adult population of persons with Down’s syndrome, systolic blood pressure and pulse pressure increased only modestly with increasing age and body-mass index.
- In this audio interview, Editor-in-Chief Eric Rubin and Deputy Editor Jane Leopold discuss research being presented at the 2024 American Heart Association Scientific Sessions. . . .
- After atrial fibrillation ablation, left atrial appendage closure was associated with a lower risk of bleeding than oral anticoagulation and was noninferior to oral anticoagulation with respect to clinical outcomes at 36 months.
- A 27-year-old woman presented to the emergency department with sudden onset of palpitations, dyspnea, and chest tightness after smoking cannabis. She also had an episode of vomiting but had no flulike symptoms.