Infectious Disease
In this randomized trial conducted over the 2019–2024 influenza seasons, baloxavir resulted in a significantly lower incidence of transmission of influenza virus from patients to household contacts than placebo.
A 65-year-old man presented with 1-day history of a rash with a bull’s-eye appearance on his left hip. One week earlier, he had removed a tick from his hip after doing yard work near the woods by his home in Tennessee.
A 3-year-old boy presented with a 6-week history of ulcerated plaques with rolled borders and satellite papules on his left lower leg. He had recently immigrated from Venezuela after a long journey by land with his family.
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- A 57-year-old man with previously treated pulmonary tuberculosis presented with a 2-week history of neck pain, headache, and tingling in his hand. MRI of the head showed numerous small, peripherally enhancing nodules.
- In this randomized trial conducted over the 2019–2024 influenza seasons, baloxavir resulted in a significantly lower incidence of transmission of influenza virus from patients to household contacts than placebo.
- In this randomized trial involving patients with noncystic fibrosis bronchiectasis, the rate of pulmonary exacerbations over a 52-week period was lower with brensocatib (10 mg or 25 mg per day) than with placebo.
- A 65-year-old man presented with 1-day history of a rash with a bull’s-eye appearance on his left hip. One week earlier, he had removed a tick from his hip after doing yard work near the woods by his home in Tennessee.
- The author describes the scientific foundations of a phase 3 study of brensocatib for the treatment of bronchiectasis.
- A 3-year-old boy presented with a 6-week history of ulcerated plaques with rolled borders and satellite papules on his left lower leg. He had recently immigrated from Venezuela after a long journey by land with his family.
- Antiviral treatment of influenza is recommended as soon as possible for hospitalized patients and for outpatients who are at increased risk for influenza-related complications.1,2 The Food and Drug Administration–approved oral antiviral agent oseltamivir is the most widely used antiviral medication for the treatment of influenza and for postexposure...
- Bronchiectasis unrelated to cystic fibrosis is the third most common chronic pulmonary disorder after asthma and chronic obstructive pulmonary disease.1 Bronchiectasis has multiple causes and is characterized by recurrent and often chronic productive cough, lower airway infection and inflammation, and irreversible bronchial dilatation.2 Irrespective of the...
- A 56-year-old woman experiencing homelessness was evaluated at this hospital because of sore throat and a pruritic rash on her face, chest, abdomen, and legs. A diagnosis was made.
- The discovery of a highly efficacious option for preexposure prophylaxis that requires only twice-yearly administration has led to the question of whether a vaccine is still needed to end the HIV epidemic.
- As the fossil-fuel industry continues to obstruct efforts to curtail pollution from its products, the health community should use strategies that have been effective in fighting other health-harming industries.
- In this NEJM Outbreaks Update, Editor-in-Chief Eric Rubin and Deputy Editor Lindsey Baden are joined by Indiana Commissioner of Public Health Lindsay Weaver to discuss the current state of avian influenza in Indiana.
- A 4-year-old girl presented with a 3-day history of fever and dry cough. A chest radiograph showed a large, rounded opacity in the left lower lobe with subtle air bronchograms.
- A patient with poorly controlled HIV infection was found to have two different strains of Treponema pallidum. Careful evaluation showed evidence for recombination between these two organisms.
- Two pandemics of mpox (formerly known as monkeypox) are ongoing, and currently, we have no proven therapies. The pandemic caused by clade I MPXV is focused in central and eastern Africa, with sporadic, travel-associated cases identified in many countries. Clade II MPXV has caused more than 100,000 cases of mpox...
- Severing the long-standing ties and scientific collaborations between the United States and the WHO and slashing U.S. financial support will have catastrophic effects on both domestic and global health.
- Treatments for mpox are needed. In this trial in the Democratic Republic of Congo, tecovirimat did not lead to faster resolution of mpox lesions than placebo in patients with clade I MPXV infection.
- The dismantling of foreign-assistance efforts has already had, and will continue to have, severe effects on vulnerable populations globally. But it also has implications for people in the United States.
- Acute otitis media occurs almost exclusively after a viral upper respiratory tract infection. Children with mild or moderate symptoms can be treated with antibiotics or closely observed.
- Almost 15 years ago, the results of the Preexposure Prophylaxis Initiative (iPrEx) trial, which showed the efficacy of oral antiretroviral agents as preexposure prophylaxis (PrEP), were reported in the Journal.1 However, only 15% of persons who would benefit from PrEP currently receive it.2 The...