Clinical Medicine

In this phase 3b, open-label, randomized, controlled trial involving adults with obesity without type 2 diabetes, tirzepatide was superior to semaglutide in reducing body weight and waist circumference.

When a low-income patient receiving home dialysis misses the bus to the clinic, his nephrologist makes a decision that launches a long-term relationship and brings unexpected meaning into his own life.

In 1965, the first federally supported community health centers were established as an experiment in government-backed primary care. But support for these institutions has recently been threatened.

An 80-year-old woman presented with a several-year history of gradual forehead enlargement and progressive hearing loss. Radiography of the skull showed marked thickening of the calvarium, with a cotton-wool appearance.

New AI-based software for generating patient notes purposely filters out social “chitchat,” but a primary care physician sees serious risks in that practice, for doctors and patients alike.

Approximately 1 in 10 persons in the United States have type 2 diabetes, and such numbers are increasing among children, teens, and young adults.¹ Adults with diabetes have struggled to lower their glucose and glycated hemoglobin levels, with only 50% reaching the recommended goal of less than 7%...

A 57-year-old man with previously treated pulmonary tuberculosis presented with a 2-week history of neck pain, headache, and tingling in his hand. MRI of the head showed numerous small, peripherally enhancing nodules.

In this trial of the aldosterone synthase inhibitor lorundrostat in participants with uncontrolled hypertension, lorundrostat was associated with greater reductions in blood pressure than placebo.

Inadequate payment is just one of many factors that negatively affect daily practice and contribute to burnout among primary care physicians. Also problematic are growing piles of nonclinical tasks.

A 28-year-old woman presented with a painful rash 5 days after a fall on sea rocks. On examination, fine, erythematous, linear lesions in a stellate distribution on the posterior right thigh were seen.

In this randomized, controlled trial involving adults with insulin-treated type 2 diabetes, automated insulin delivery resulted in lower glycated hemoglobin levels than continuous glucose monitoring alone.

Pegivirus hominis, a common virus that has not been linked to specific diseases, was detected in CSF, serum, and brain tissue from four patients with encephalomyelitis, with evidence of independent replication in the CNS.

A 70-year-old man was admitted to the hospital for weakness, anorexia, and weight loss. Rapidly progressive altered mental status developed shortly after admission. A diagnosis was made.

When a dying patient’s parents refuse to give up hope, her physician opts to hope with them, going to unusual lengths to provide a last treatment he knows will be futile.

This feature about a woman with device-detected atrial fibrillation offers a case vignette accompanied by two essays, one supporting the initiation of anticoagulant therapy and the other recommending continuation of antiplatelet therapy.

Chronic obstructive pulmonary disease (COPD) remains a complex and persistent medical challenge with major public health implications and a substantial economic burden worldwide.¹ Among patients hospitalized with acute exacerbations, the 1-year mortality is more than 25%, and the 5-year mortality is more than 50%; a substantial percentage continue...

An 80-year-old woman presented with a 3-day history of abdominal pain. Imaging revealed numerous small gallstones in the gallbladder and cystic duct, consistent with cholecystitis.

Lepodisiran, an extended-duration, small interfering RNA, reduced lipoprotein(a) concentrations in participants with elevated levels.

A pediatric oncologist’s outlook and practice are transformed when a 10-year-old cricket fanatic with acute lymphoblastic leukemia touches her heart.

Unhealthy alcohol use is common and includes severe alcohol use disorder. Screening tests identify patients who may benefit from preventive counseling, medications, or more intensive intervention.