Hematology/Oncology
A 29-year-old woman was admitted to the hospital because of sore throat and peritonsillar swelling and bleeding. Symptoms did not abate with antimicrobial therapy. What is the diagnosis?
CD19-specific CAR T cells engineered to secrete interleukin-18 were used to treat patients with lymphoma after previous CAR T failure, with a complete or partial response of 81% and a complete response of 52%.
Combined treatment with a tyrosine kinase inhibitor and blinatumomab has converted Ph-positive ALL, once the most deadly hematologic cancer, to a disease with long-term survival of 75 to 80%.
Among patients with smoldering multiple myeloma at high risk for progression, progression-free survival at 5 years was 63.1% with daratumumab monotherapy, as compared with 40.8% with active monitoring.
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- Multiple sclerosis is the most common cause of progressive neurologic disability in young adults. There had been no treatments for the disease, except for glucocorticoids, which were used for more than 25 years before they were shown to reduce the duration and severity of acute relapses but to have no...
- Combined treatment with a tyrosine kinase inhibitor and blinatumomab has converted Ph-positive ALL, once the most deadly hematologic cancer, to a disease with long-term survival of 75 to 80%.
- A 29-year-old woman was admitted to the hospital because of sore throat and peritonsillar swelling and bleeding. Symptoms did not abate with antimicrobial therapy. A diagnosis was made.
- In two trials in relapsing multiple sclerosis, tolebrutinib (a brain-penetrant BTK inhibitor) was not superior to teriflunomide at reducing annualized relapse rates.
- CD19-specific CAR T cells engineered to secrete interleukin-18 were used to treat patients with lymphoma after previous CAR T failure, with a complete or partial response of 81% and a complete response of 52%.
- Multiple myeloma is preceded by an asymptomatic expansion of clonal plasma cells that is detected clinically and described as smoldering multiple myeloma. Studies have identified a fraction of cases of smoldering multiple myeloma that are characterized by a high risk of early progression to multiple myeloma. Progression to multiple myeloma...
- Among patients with smoldering multiple myeloma at high risk for progression, progression-free survival at 5 years was 63.1% with daratumumab monotherapy, as compared with 40.8% with active monitoring.
- When a dying patient’s parents refuse to give up hope, her physician opts to hope with them, going to unusual lengths to provide a last treatment he knows will be futile.
- The author describes the scientific foundations and implications of a study on variant EPO and erythrocytosis.
- This phase 1–2 study involving nine children with leukocyte adhesion deficiency type 1 showed significantly better survival with lentiviral gene therapy without hematopoietic stem-cell transplantation than that in historical controls.
- Alcohol policy interventions, including those that increase alcohol taxes, raise the drinking and purchase age, reduce days or hours of sale, and impose strong marketing bans, reduce alcohol consumption.
- Relapsed Burkitt’s lymphoma is nearly always fatal. Three patients had a complete metabolic response with the combination of the bispecific antibody glofitamab and the antibody–drug conjugate polatuzumab vedotin.
- In six families with familial polycythemia, EPO variants led to the production of a hepatic-like erythropoietin that had an altered glycosylation pattern and was more active than the renal form.
- A pediatric oncologist’s outlook and practice are transformed when a 10-year-old cricket fanatic with acute lymphoblastic leukemia touches her heart.
- Unhealthy alcohol use is common and includes severe alcohol use disorder. Screening tests identify patients who may benefit from preventive counseling, medications, or more intensive intervention.
- A key function of leukocytes is their ability to migrate and extravasate into tissues, which is facilitated by cell surface molecules that promote adhesion to the vascular endothelium. The β2 integrin molecule (also known as CD18) is the common component of four molecular complexes that play a crucial...
- Research generally suggests that routine surveillance after cancer treatment finds more recurrences — leading to more surgery, chemotherapy, and radiation — without affecting the risk of death.
- Despite greater recognition of the harms of alcohol use, U.S. alcohol taxes are at all-time lows. A reexamination may help inform national debates about revenue generation, spending cuts, and public health.
- Among patients with tumors harboring tyrosine kinase domain mutations who received zongertinib (a selective inhibitor of the HER2 tyrosine kinase), 71% had a response, and median progression-free survival was 12.4 months.
- Neoadjuvant PD-1 blockade with dostarlimab led to organ preservation in a high proportion of patients with early-stage mismatch repair–deficient tumors, with no compromise of surgical options.