Gastroenterology
Food contains more than 139,000 molecules, which influence nearly half the human proteome. Systematic analysis of food–chemical interactions can potentially advance nutrition science and drug discovery.
In this interim analysis of a phase 3 trial involving 800 patients with metabolic dysfunction–associated steatohepatitis, once-weekly semaglutide improved liver histologic results at 72 weeks.
In patients with compensated cirrhosis from metabolic dysfunction–associated steatohepatitis, efruxifermin did not significantly reduce fibrosis at 36 weeks.
1-20 of 4754 results
- Overweight and obesity represent addressable proximal drivers of chronic disease.1 The prevalence of overweight and obesity is increasing around the world; by 2050, projections indicate that more than half the adult population worldwide will be living with overweight and obesity, most prominently in China (an estimated 627 million...
- Once-weekly mazdutide, a glucagon-like peptide-1 and glucagon receptor dual agonist, provided clinically relevant reduction in body weight in Chinese adults with obesity or overweight.
- In this phase 3b, open-label, randomized, controlled trial involving adults with obesity without type 2 diabetes, tirzepatide was superior to semaglutide in reducing body weight and waist circumference.
- In patients with compensated cirrhosis from metabolic dysfunction–associated steatohepatitis, efruxifermin did not significantly reduce fibrosis at 36 weeks.
- Food contains more than 139,000 molecules, which influence nearly half the human proteome. Systematic analysis of food–chemical interactions can potentially advance nutrition science and drug discovery.
- An 80-year-old woman presented with a 3-day history of abdominal pain. Imaging revealed numerous small gallstones in the gallbladder and cystic duct, consistent with cholecystitis.
- Unhealthy alcohol use is common and includes severe alcohol use disorder. Screening tests identify patients who may benefit from preventive counseling, medications, or more intensive intervention.
- A 26-year-old man presented with acute leg pain and loss of function in the left leg. CTA of the abdomen showed a saddle embolus at the aortoiliac junction. A heterogeneous mass was seen in the left atrium.
- A 61-year-old man with a history of hypertension, type 2 diabetes mellitus, alcohol use disorder, and chronic pancreatitis was referred to the emergency department for an elevated serum creatinine level.
- In this interim analysis of a phase 3 trial involving 800 patients with metabolic dysfunction–associated steatohepatitis, once-weekly semaglutide improved liver histologic results at 72 weeks.
- Neoadjuvant PD-1 blockade with dostarlimab led to organ preservation in a high proportion of patients with early-stage mismatch repair–deficient tumors, with no compromise of surgical options.
- FcRn protects IgG and albumin from catabolism, transports IgG across the placenta, and regulates IgG function. Blocking or augmenting FcRn can decrease autoimmune antibodies and enhance drug delivery.
- This review considers enteral nutrition in the context of disease-related malnutrition, provides evidence for the use of enteral nutrition in hospitalized patients, and discusses practice considerations.
- A 16-year-old girl presented with a 2-month history of leg swelling. Laboratory results were notable for a low albumin level. Abdominal CT revealed diffuse thickening of the gastric wall with enlarged gastric folds.
- Exome and genome sequence analysis, together with follow-up functional analyses, yielded a genetic diagnosis in 62 of 129 infants (48%) with congenital diarrhea and enteropathy.
- Among participants with type 2 diabetes and cardiovascular disease, chronic kidney disease, or both, oral semaglutide (14 mg) was associated with a lower risk of cardiovascular events than placebo after 4 years of follow-up.
- A 59-year-old man with a history of metabolic dysfunction–associated steatotic liver disease had an enlarging liver mass. Biopsy showed hepatocellular carcinoma. Management decisions were made.
- In a trial involving 135 participants with IgG4-related disease, inebilizumab was associated with significantly lower flare risk and greater likelihood of complete remission than placebo at 1 year.
- A full-term baby boy was transferred to the NICU at 30 hours of age with abdominal distention and failure to pass meconium. An abdominal radiograph showed dilated loops of small intestine.
- IgG4-related disease is an increasingly recognized fibroinflammatory condition with protean manifestations. The disorder is characterized by inflammatory mass lesions that can involve many different organs and organ systems — including the pancreas and biliary tract, orbital structures, salivary and lacrimal glands, lungs, retroperitoneum, and kidneys — and can also cause...